Clinicopathological Features of Canine Neuroaxonal Dystrophy and Cerebellar Cortical Abiotrophy in Papillon and Papillon-related Dogs
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چکیده
منابع مشابه
Ultrastructural features of canine neuroaxonal dystrophy in a Papillon dog
Neuroaxonal dystrophy (NAD) is a neurodegenerative disease characterized by severe axonal swelling (spheroids) throughout the nervous system. In dogs, NAD has been reported in several breeds and a missense mutation in PLA2G6 gene has recently been identified in the Papillon dog NAD. Here we performed ultrastructural analysis to clarify the detailed ultrastructural features of the Papillon dog N...
متن کاملCASE REPORT Cerebellar cortical abiotrophy in Lagotto Romagnolo dogs
Abiotrophy is a term used to describe premature tissue degeneration typically because of an intrinsic abnormality in the cell’s structure, altering metabolic processes necessary for cell vitality and function (deLahunta 1990). One of the more common abiotrophies in domestic animals are those affecting the cerebellar cortex (Summers and others 1994). Typically, the predominant histological lesio...
متن کاملIdentification of the PLA2G6 c.1579G>A Missense Mutation in Papillon Dog Neuroaxonal Dystrophy Using Whole Exome Sequencing Analysis
Whole exome sequencing (WES) has become a common tool for identifying genetic causes of human inherited disorders, and it has also recently been applied to canine genome research. We conducted WES analysis of neuroaxonal dystrophy (NAD), a neurodegenerative disease that sporadically occurs worldwide in Papillon dogs. The disease is considered an autosomal recessive monogenic disease, which is h...
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Serebellar abiotrofi birçok hayvan türünde cinsiyetten bağımsız, otozomal, kalıtsal nitelikte tipik olarak Purkinje hücrelerinin progresif kaybıyla karakterize bir durumdur. Mevcut vakada travma veya başka hastalık hikayesi olmayan ataksi gözlenen bir haftalık Samoyed ırkı bulunmaktadır. Fiziksel muayenede kontrolsüz hareketler, gövdede ılımlı ataksi ve başta şiddetli titremeler gözlendi. Ayrıc...
متن کاملManagement of Papillon Lefevre Syndrome
It is a rare, autosomal recessive disorder occurring between the f irst and fi f th years of l i fe and is characterized by palmoplantar keratoderma and periodontitis fol lowed by the premature shedding of both primary and permanent teeth. The teeth are affected in the order of their eruption, exhibiting inflammation of the periodontal tissue, bleeding of the gums, pocket formation, loosening o...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2007
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.69.1047